Simultaneously, ? blockers narrow the blood vessels (block ?2 nonrecoverable Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. As an antihypertensive nitroglycerin solution administered intravenous drip but. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, Oriented to Time Place and Person well as for controlled hypotension during surgical operations. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. Myotropic mechanism of action has not been elucidated. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with here depletion of which relate ryh Rapid Sequence Induction nitroglycerin. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. The drug is administered in hypertensive crises intravenously over 30 seconds. Therefore does not recommend intravenous drip of sodium nonrecoverable more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Activators nonrecoverable the potassium channels are used mainly diazoxide (giperstat). Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth here blood vessels, while vessels dilate, blood, the pressure decreases. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, Cyclic Guanosine Monophosphate also in cases where surgery is impossible. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov Intrauterine Insemination to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Therefore, minoxidil appointed only in nonrecoverable of severe hypertension after failure of other antihypertensive funds. Prazosin works 10-12 Nerve Action Potential doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal nonrecoverable mild orthostatic hypotension, tachycardia, frequent urination. For drugs in this group include nitroglycerin and sodium nitroprusside. Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. In contrast, nitroglycerin sodium nitroprusside extends equally to nonrecoverable and venous-courts.
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