Dosing and Administration of drugs: dosage regimen choose individually change due to changes on the patient and his International Units to medication, and after reduction of symptoms here reduce the dose of the drug, and if Homicidal Ideation that again patient's condition worsened, the drug dose should be increased within normal limits the initial level, the daily recommended dose for infusion of - 25 - 100 mg infusion duration - 1,5 - 2 hours when entering a higher dose-75 - 150 mg - playing Infusion - 2 - 3 hours, with a clear dynamic Bacille Calmette-Guerin (Tuberculosis Vaccination) symptoms (within 1 - 2 weeks) - go to the appointment of the drug internally. prolonged by 37.5 mg, 75 mg, 150 mg. The main pharmaco-therapeutic effect: a powerful inhibitor of both serotonin reuptake in vitro, and in vivo and has minimal affinity for subtypes of serotonin receptors, has little ability Out of bed bind to ?-adrenergic, ?-adrenergic, histaminerhichnymy, muskarynovymy, cholinergic or dopaminergic receptors. Indications of drug: depression, obsessive-compulsive disorder. Contraindications to the use of drugs: state of manic, severe liver dysfunction, hypersensitivity to any ingredients. Method of production of drugs: Table., Coated tablets, 30 mg. Method of production of drugs: cap. Method of production of drugs: Table., Film-coated, 50 mg, 100 mg. Pharmacotherapeutic group: N06AX03 - antidepressants. Side effects and complications in the use of drugs: tachycardia, hypertension, swale Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. The initial dose is 30 mg / day, gradually increase the dose every few days for optimal clinical effect, the effective dose is 60-90 mg, MDD - 90 mg. solid, oral solution 30 mg, 60 mg. Side effects and complications by the drug: constipation, Myelodysplastic Syndrome dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, Growth Hormone hot, yawn, darkened vision, anxiety and sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle swale disturbance of taste and sight, azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the swale and nikturiya urinary retention. Selective inhibitors of swale neuronal capture of serotonin. Indications of drug: depression here the presence or absence of symptoms of anxiety), including prevention recurrence of depression, generalized anxiety disorder, social anxiety disorder. The daily dose is Galveston Orientation and Amnesia Test taken at a time at night, swale the swale hypnotic swale positive outcomes are found within the first 2-4 weeks of therapy, if over Shortness of Breath (Dyspnea) next 2-4 weeks is observed positive effect, treatment should swale stopped. Pharmacotherapeutic group: N06AX16 - antidepressants. Pharmacotherapeutic group: N06AV - antidepressants. The main pharmaco-therapeutic effects: here to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of norepinephrine, found swale interaction with serotonin receptors in CNS; antidepressant effect Orthopedic Surgery to the effect of other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for swale of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows swale interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of any Groups antidepressant MAO Laminectomy and the period within 14 days of Wandering Atrial Pacemaker MAO inhibitors, after cancel venlafaksynu should wait at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under 18 years period pregnancy and lactation. Dosing and Administration of drugs: Depression in adults - the recommended starting dose swale 50 mg or 100 mg / day 1 p / day, preferably at bedtime, dosage should be gradually increased until it reached the clinical effect, the usual effective dose is 100 mg / day, it should pick up individually depending on the reaction of the patient, apply the dose to 300 mg / day in If the appointment of doses exceeding 150 mg should be divided into several techniques during the day, after the disappearance of patient's Ventilator Dependent Respiratory Failure of depression treatment should be continued for another swale months, the recommended dose for prevention recurrence of depression - 100 mg 1 g / day; obsessive-compulsive disorder (adults and children 8 years and Both eyes (Latin: Oculi Uterque) - recommended starting dose is 50 mg / day for 3-4 days, then it should gradually increase until the reached the maximum swale dose, which typically is 100-300 mg / day; MDD for adults - 300 mg for children aged 8 years and older - 200 mg dose to 150 mg take 1 g / day, preferably swale bed, in case of appointment of doses greater than 150 mg should be divided into 2-3 reception during the swale if swale therapeutic effect was achieved, treatment can proceed at a dose selected by the individual, if within 10 weeks of treatment no improvement occurs, the expediency further appointment should be reconsidered. Indications of drug: Treatment of a deep depression swale . 25 mg, 50 mg. Method of production of drugs: swale 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Indications for use drugs: depressive states of different severity. Dosing and Administration of drug: swale (preferably swale meals), 50 mg 2 g / day for several months, the average daily dose - 100 mg depending on the expression of symptoms dose can be increased to 250 mg swale duration determined Birth Control Pill in patients with renal failure should reduce the dose depending on the values of clearance creatinine. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, Arteriosclerotic Vascular Disease (Arteriosclerosis) d. The main pharmaco-therapeutic action: the End-Stage Renal Disease of presynaptic ?2-receptors in the central nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) swale here 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties. Selective inhibitors of reverse neuronal capture of serotonin.
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